Rebecca Prosser, an associate professor in the Department of Biochemistry and Cellular and Molecular Biology, has just been awarded a grant from the National Institutes of Health for $1.4 million to study the effects of drinking alcohol on the brain area that controls sleep/wake patterns and other daily rhythms in mammals. This funding will provide four years of support for her work on alcohol effects on the brain. The 24-hour activity patterns that are experienced by mammals, or circadian rhythms, are regulated through a specific center in the brain called the suprachiasmatic nucleus. Prosser, a neurobiologist, has made her career, first at Stanford as a postdoctoral fellow, and now as a faculty member at UTK, studying circadian rhythms. This newest award resulted from studies she has performed over the last several years with a pilot grant from the NIH.
Mou, X., Peterson, C.B., and Prosser, R.A. (2009). Tissue-type plasminogen activator-plasmin-BDNF modulate glutamate-induced phase shifts of the mouse suprachiasmatic circadian clock in vitro. Eur. J. Neurosci. 30 (8): 1451-1460.
Prosser, R.A., and Glass, J.D. (2009). The mammalian circadian clock exhibits acute tolerance to ethanol. Alcohol. Clin. Expt. Res. 33 (12): 2088-2093.
Prosser, R.A., McElroy, B., Zakaria, A., and Glass, J.D. (2009). Ethanol modulates mammalian circadian clock phase resetting through extrasynaptic GABA receptor activation. Neuroscience 164(2):842-8.
Ruby, C.L., Brager, A.J., DePaul, M.A. Prosser, R.A., and Glass, J.D. (2009). Chronic ethanol disrupts circadian behavior and photic phase-resetting in the hamster. Am. J. Physiol. 297: R729-R737.
Ruby, C.L., Prosser, R.A., and Glass, J.D. (2009). Acute Ethanol Impairs Photic and Nonphotic Circadian Phase-Resetting in the Syrian Hamster. Am. J. Physiol. 296: R411-R418.
Prosser, R.A. and Glass, J.D. (2008). Acute ethanol modulates glutamatergic and serotonergic phase shifts of the mouse circadian clock in vitro. Neuroscience 152: 837-848.
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